SLAC National Accelerator Laboratory Email: fdfuller@slac.stanford.edu Phone: (cell) 612-987-8472, (office) 650-926-3235

Employment

Position	Duration
Panofsky Fellow SLAC National Accelerator Laboratory, Linac Coherent Light Source Principle Investigator: Franklin Fuller	2017-Present
Ruth Kirschstein Postdoctoral Fellow Lawrence Berkeley National Laboratory, Molecular Biophysics and Integrated Bioimaging Division Principle Investigator: Franklin Fuller Sponsor: Junko Yano	2015-2017
Chemistry Postdoctoral Fellow Lawrence Berkeley National Laboratory, Molecular Biophysics and Integrated Bioimaging Division Principle Investigator: Junko Yano & Vittal Yachandra	2014-2015
Graduate Student Research Assistant University of Michigan, Department of Biophysics Principle Investigator: Jennifer Ogilvie	2009-2014

Education

Degree	Completion Date
PhD Biophysics University of Michigan, Department of Biophysics Dissertation: Observations of Coherence in Oxygenic Photosynthesis Advisor: Jennifer Ogilvie	August 2014
BS Physics University of Minnesota, Department of Physics	May 2008
BA Mathematics University of Minnesota, Department of Mathematics Thesis: Reaction Diffusion in Protein Expression and Actin Polymerization Advisor: Richard Moeckel	May 2008

Publications

Resonant X-ray Emission spectroscopy from broadband stochastic pulses at an X-ray free electron laser Fuller, F. D., Loukianov, A., Takanashi, T., You, D., Li, Y., Ueda, K., Fransson, T., Yabashi, M., Katayama, T., Weng, T., Alonso-Mori, R., Bergmann, U., Kern, J., Yachandra, V. K., Wernet, P., Yano, J., et al. Communications Chemistry 2021; 4 (84)

High-Resolution XFEL Structure of the Soluble Methane Monooxygenase Hydroxylase Complex with its Regulatory Component at Ambient Temperature in Two Oxidation States Srinivas, V., Banerjee, R., Lebrette, H., Jones, J. C., Aurelius, O., Kim, I., Pham, C. C., Gul, S., Sutherlin, K. D., Bhowmick, A., John, J., Bozkurt, E., Fransson, T., Aller, P., Butryn, A., Bogacz, I., Simon, P., Keable, S., Britz, A., Tono, K., Kim, K., Park, S., Lee, S., Park, J., Alonso-Mori, R., Fuller, F. D., Batyuk, A., Brewster, A. S., Bergmann, U., Sauter, N. K., Orville, A. M., Yachandra, V. K., Yano, J., Lipscomb, J. D., Kern, J., Hogbom, M. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2020; 142 (33): 14249–66

Observation of Seeded Mn K beta Stimulated X-Ray Emission Using Two-Color X-Ray Free-Electron Laser Pulses Kroll, T., Weninger, C., Fuller, F. D., Guetg, M. W., Benediktovitch, A., Zhang, Y., Marinelli, A., Alonso-Mori, R., Aquila, A., Liang, M., Koglin, J. E., Koralek, J., Sokaras, D., Zhu, D., Kern, J., Yano, J., Yachandra, V. K., Rohringer, N., Lutman, A., Bergmann, U. PHYSICAL REVIEW LETTERS 2020; 125 (3)

Untangling the sequence of events during the S2 S3 transition in photosystem II and implications for the water oxidation mechanism. Ibrahim, M., Fransson, T., Chatterjee, R., Cheah, M. H., Hussein, R., Lassalle, L., Sutherlin, K. D., Young, I. D., Fuller, F. D., Gul, S., Kim, I., Simon, P. S., de Lichtenberg, C., Chernev, P., Bogacz, I., Pham, C. C., Orville, A. M., Saichek, N., Northen, T., Batyuk, A., Carbajo, S., Alonso-Mori, R., Tono, K., Owada, S., Bhowmick, A., Bolotovsky, R., Mendez, D., Moriarty, N. W., Holton, J. M., Dobbek, H., Brewster, A. S., Adams, P. D., Sauter, N. K., Bergmann, U., Zouni, A., Messinger, J., Kern, J., Yachandra, V. K., Yano, J. Proceedings of the National Academy of Sciences of the United States of America 2020

Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases Miller, K. R., Paretsky, J. D., Follmer, A. H., Heinisch, T., Mittra, K., Gul, S., Kim, I., Fuller, F. D., Batyuk, A., Sutherlin, K. D., Brewster, A. S., Bhowmick, A., Sauter, N. K., Kern, J., Yano, J., Green, M. T., Ward, T. R., Borovik, A. S. INORGANIC CHEMISTRY 2020; 59 (9): 6000–6009

Photoreversible interconversion of a phytochrome photosensory module in the crystalline state. Burgie, E. S., Clinger, J. A., Miller, M. D., Brewster, A. S., Aller, P., Butryn, A., Fuller, F. D., Gul, S., Young, I. D., Pham, C. C., Kim, I., Bhowmick, A., O’Riordan, L. J., Sutherlin, K. D., Heinemann, J. V., Batyuk, A., Alonso-Mori, R., Hunter, M. S., Koglin, J. E., Yano, J., Yachandra, V. K., Sauter, N. K., Cohen, A. E., Kern, J., Orville, A. M., Phillips, G. N., Vierstra, R. D. Proceedings of the National Academy of Sciences of the United States of America 2019

XANES and EXAFS of dilute solutions of transition metals at XFELs. Chatterjee, R., Weninger, C., Loukianov, A., Gul, S., Fuller, F. D., Cheah, M. H., Fransson, T., Pham, C. C., Nelson, S., Song, S., Britz, A., Messinger, J., Bergmann, U., Alonso-Mori, R., Yachandra, V. K., Kern, J., Yano, J. Journal of synchrotron radiation 2019; 26 (Pt 5): 1716–2

The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source Sierra, R. G., Batyuk, A., Sun, Z., Aquila, A., Hunter, M. S., Lane, T. J., Liang, M., Yoon, C., Alonso-Mori, R., Armenta, R., Castagna, J., Hollenbeck, M., Osier, T. O., Hayes, M., Aldrich, J., Curtis, R., Koglin, J. E., Rendahl, T., Rodriguez, E., Carbajo, S., Guillet, S., Paul, R., Hart, P., Nakahara, K., Carini, G., DeMirci, H., Dao, E., Hayes, B. M., Rao, Y. P., Chollet, M., Feng, Y., Fuller, F. D., Kupitz, C., Sato, T., Seaberg, M. H., Song, S., van Driel, T. B., Yavas, H., Zhu, D., Cohen, A. E., Wakatsuki, S., Boutet, S. JOURNAL OF SYNCHROTRON RADIATION 2019; 26: 346–57

Structures of the intermediates of Kok’s photosynthetic water oxidation clock. Kern, J., Chatterjee, R., Young, I. D., Fuller, F. D., Lassalle, L., Ibrahim, M., Gul, S., Fransson, T., Brewster, A. S., Alonso-Mori, R., Hussein, R., Zhang, M., Douthit, L., de Lichtenberg, C., Cheah, M. H., Shevela, D., Wersig, J., Seuffert, I., Sokaras, D., Pastor, E., Weninger, C., Kroll, T., Sierra, R. G., Aller, P., Butryn, A., Orville, A. M., Liang, M., Batyuk, A., Koglin, J. E., Carbajo, S., Boutet, S., Moriarty, N. W., Holton, J. M., Dobbek, H., Adams, P. D., Bergmann, U., Sauter, N. K., Zouni, A., Messinger, J., Yano, J., Yachandra, V. K. Nature 2018

X-ray Emission Spectroscopy as an in Situ Diagnostic Tool for X-ray Crystallography of Metalloproteins Using an X-ray Free-Electron Laser. Fransson, T., Chatterjee, R., Fuller, F. D., Gul, S., Weninger, C., Sokaras, D., Kroll, T., Alonso-Mori, R., Bergmann, U., Kern, J., Yachandra, V. K., Yano, J. Biochemistry 2018

Stimulated X-Ray Emission Spectroscopy in Transition Metal Complexes Kroll, T., Weninger, C., Alonso-Mori, R., Sokaras, D., Zhu, D., Mercadier, L., Majety, V. P., Marinelli, A., Lutman, A., Guetg, M. W., Decker, F., Boutet, S., Aquila, A., Koglin, J., Koralek, J., DePonte, D. P., Kern, J., Fuller, F. D., Pastor, E., Fransson, T., Zhang, Y., Yano, J., Yachandra, V. K., Rohringer, N., Bergmann, U. PHYSICAL REVIEW LETTERS 2018; 120 (13): 133203

Soft x-ray absorption spectroscopy of metalloproteins and high-valent metal-complexes at room temperature using free-electron lasers Kubin, M., Kern, J., Gul, S., Kroll, T., Chatterjee, R., Loechel, H., Fuller, F. D., Sierra, R. G., Quevedo, W., Weniger, C., Rehanek, J., Firsov, A., Laksmono, H., Weninger, C., Alonso-Mori, R., Nordlund, D. L., Lassalle-Kaiser, B., Glownia, J. M., Krzywinski, J., Moeller, S., Turner, J. J., Minitti, M. P., Dakovski, G. L., Koroidov, S., Kawde, A., Kanady, J. S., Tsui, E. Y., Suseno, S., Han, Z., Hill, E., Taguchi, T., Borovik, A. S., Agapie, T., Messinger, J., Erko, A., Foehlisch, A., Bergmann, U., Mitzner, R., Yachandra, V. K., Yano, J., Wernet, P. STRUCTURAL DYNAMICS 2017; 4 (5): 054307

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers. Franklin D Fuller, Sheraz Gul, Ruchira Chatterjee, E Sethe Burgie, Iris D Young, Hugo Lebrette, Vivek Srinivas, Aaron S Brewster, Tara Michels-Clark, Jonathan A Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper de Lichtenberg, Rana Hussein, Christopher J Pollock, Miao Zhang, Claudiu A Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D Miller, Muhamed Amin, Sergey Koroidov, Christian G Roessler, Marc Allaire, Raymond G Sierra, Peter T Docker, James M Glownia, Silke Nelson, Jason E Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K Boal, J Martin Bollinger Jr, Carsten Krebs, Martin Högbom, George N Phillips Jr, Richard D Vierstra, Nicholas K Sauter, Allen M Orville, Jan Kern, Vittal K Yachandra & Junko Yano. Nature Methods 2017; v 14.4, pp 443-449.

Structure of photosystem II and substrate binding at room temperature Young, I. D., Ibrahim, M., Chatterjee, R., Gul, S., Fuller, F. D., Koroidov, S., Brewster, A. S., Tran, R., Alonso-Mori, R., Kroll, T., Michels-Clark, T., Laksmono, H., Sierra, R. G., Stan, C. A., Hussein, R., Zhang, M., Douthit, L., Kubin, M., de Lichtenberg, C., Long Vo Pham, L. V., Nilsson, H., Cheah, M. H., Shevela, D., Saracini, C., Bean, M. A., Seuffert, I., Sokaras, D., Weng, T., Pastor, E., Weninger, C., Fransson, T., Lassalle, L., Braeuer, P., Aller, P., Docker, P. T., Andi, B., Orville, A. M., Glownia, J. M., Nelson, S., Sikorski, M., Zhu, D., Hunter, M. S., Lane, T. J., Aquila, A., Koglin, J. E., Robinson, J., Liang, M., Boutet, S., Lyubimov, A. Y., Uervirojnangkoorn, M., Moriarty, N. W., Liebschner, D., Afonine, P. V., Waterman, D. G., Evans, G., Wernet, P., Dobbek, H., Weis, W. I., Brunger, A. T., Zwart, P. H., Adams, P. D., Zouni, A., Messinger, J., Bergmann, U., Sauter, N. K., Kern, J., Yachandra, V. K., Yano, J. NATURE 2016; 540 (7633): 453

X-ray absorption spectroscopy using a self-seeded soft X-ray free-electron laser Kroll, T., Kern, J., Kubin, M., Ratner, D., Gul, S., Fuller, F. D., Loechel, H., Krzywinski, J., Lutman, A., Ding, Y., Dakovski, G. L., Moeller, S., Turner, J. J., Alonso-Mori, R., Nordlund, D. L., Rehanek, J., Weniger, C., Firsov, A., Brzhezinskaya, M., Chatterjee, R., Lassalle-Kaiser, B., Sierra, R. G., Laksmono, H., Hill, E., Borovik, A., Erko, A., Foehlisch, A., Mitzner, R., Yachandra, V. K., Yano, J., Wernet, P., Bergmann, U. OPTICS EXPRESS 2016; 24 (20): 22469-22480

Concentric-flow electrokinetic injector enables serial crystallography of ribosome and photosystem II Sierra, R. G., Gati, C., Laksmono, H., Dao, E. H., Gul, S., Fuller, F., Kern, J., Chatterjee, R., Ibrahim, M., Brewster, A. S., Young, I. D., Michels-Clark, T., Aquila, A., Liang, M., Hunter, M. S., Koglin, J. E., Boutet, S., Junco, E. A., Hayes, B., Bogan, M. J., Hampton, C. Y., Puglisi, E. V., Sauter, N. K., Stan, C. A., Zouni, A., Yano, J., Yachandra, V. K., Soltis, S. M., Puglisi, J. D., DeMirci, H. NATURE METHODS 2016; 13 (1): 59-?

Experimental Implementations of Two-Dimensional Fourier Transform Electronic Spectroscopy Fuller, F. D., Ogilvie, J. P. ANNUAL REVIEW OF PHYSICAL CHEMISTRY 2015; 66: 667–90

Vibronic coherence in oxygenic photosynthesis Fuller, F. D., Pan, J., Gelzinis, A., Butkus, V., Senlik, S., Wilcox, D. E., Yocum, C. F., Valkunas, L., Abramavicius, D., Ogilvie, J. P. NATURE CHEMISTRY 2014; 6 (8): 706–11

Pulse shaping based two-dimensional electronic spectroscopy in a background free geometry Fuller, F. D., Wilcox, D. E., Ogilvie, J. P. OPTICS EXPRESS 2014; 22 (1): 1018–27

Fast second-harmonic generation frequency-resolved optical gating using only a pulse shaper Wilcox, D. E., Fuller, F. D., Ogilvie, J. P. OPTICS LETTERS 2013; 38 (16): 2980–83

Tight-binding model of the photosystem II reaction center: application to two-dimensional electronic spectroscopy Gelzinis, A., Valkunas, L., Fuller, F. D., Ogilvie, J. P., Mukamel, S., Abramavicius, D. NEW JOURNAL OF PHYSICS 2013; 15

Simulations of the Two-Dimensional Electronic Spectroscopy of the Photosystem II Reaction Center Lewis, K. M., Fuller, F. D., Myers, J. A., Yocum, C. F., Mukamel, S., Abramavicius, D., Ogilvie, J. P. JOURNAL OF PHYSICAL CHEMISTRY A 2013; 117 (1): 34–41

Continuum probe two-dimensional electronic spectroscopy of the photosystem II reaction center Fuller, F. D., Ogilvie, J. P., Chergui, M., Taylor, A., Cundiff, S., DeVivieRiedle, R., Yamagouchi, K. E D P SCIENCES. 2013

Effects of chirp on two-dimensional Fourier transform electronic spectra Tekavec, P. F., Myers, J. A., Lewis, K. M., Fuller, F. D., Ogilvie, J. P. OPTICS EXPRESS 2010; 18 (11): 11015–24

Conformational dynamics of single pre-mRNA molecules during in vitro splicing Abelson, J., Blanco, M., Ditzler, M. A., Fuller, F., Aravamudhan, P., Wood, M., Villa, T., Ryan, D. E., Pleiss, J. A., Maeder, C., Guthrie, C., Walter, N. G. NATURE STRUCTURAL & MOLECULAR BIOLOGY 2010; 17 (4): 504–U156

Invited (oral) presentations

SSRL/LCLS User’s Meeting Nonlinear Science at the Tender X-ray Instrument Workshop, September 2021. Double Core-holes studied with multi-dimensional absorption spectroscopy

SSRL/LCLS User’s Meeting Machine Learning Workshop, September, 2018 Gaussian Processes for new and old spectroscopic measurements in the low photon counting regime

SSRL/LCLS User’s Meeting Sample Delivery Workshop, September, 2018 Flexible sample delivery by combining droplet on demand with fixed target systems

European XFEL User’s Meeting, January, 2018 Drop on Demand Sample Delivery for Studying Biocatalysts in Action at XFELs

Biosciences Expert Advisory Council (Postdoc Research Highlights), February 2017 Studying reactive intermediates in metalloenzyme catalysis at an x-ray free electron laser

Division Retreat, Molecular Biophysics and Integrated Bioimaging Division, LBNL, November 2016 Transient X-ray Emission Spectroscopy on the PSII OEC at an X-ray Free Electron Laser

Submitted (oral) presentations

SPIE Optics and Photonics Hard X-Ray, Gamma-Ray, and Neutron Detector Physics, August, 2021 Analytic von Hamos geometry optimization and calibration

SSRL/LCLS User’s Meeting Worshop on Automated Analysis and Control for X-ray Experiments Streaming Variational Inference as a decision-making aid during data collection

AI@SLAC Seminar, June 2018 Rapid Gaussian Process Training via Structured Low-Rank Kernel Approximation of Gridded Measurements

Gordon Research Seminar (GRS) Bioinorganic Chemistry, January 2017 High Throughput Transient X-ray Crystallography and Emission Spectroscopy on the Metalloenzymes at an X-ray Free Electron Laser

International Photosynthesis Congress, August 2016 Transient X-ray Crystallography and Emission Spectroscopy on the PSII OEC at an X-ray Free Electron Laser using a High Throughput Instrument.

International Photosynthesis Congress, Maastricht, Netherlands, August 2016 (chosen from poster) Transient X-ray Crystallography and Emission Spectroscopy on the PSII OEC at an X-ray Free Electron Laser using a High Throughput Instrument.

Western Photosynthesis Meeting, January 2016 A High Throughput Instrument to study Water Oxidation in Thermosynechococcus Elongatus using X-ray Crystallography and Emission Spectroscopy at an X-ray Free Electron Laser.

Bioenergetics Seminar series, Molecular Biophysics and Integrated Bioimaging Division, LBNL, September 2016 ‘Would you like to use an XFEL (to study biological questions)?’

German Physical Society Spring Meeting Hannover, March 2013 2DES in a modified pulse shaped pump probe geometry, with application to the photosystem II reaction center’

Poster presentations

Lab Directed Research and Development Open House, February 2020 Using Simulations to Aid Signal Reconstruction

Lab Directed Research and Development Open House, February 2019 Gaussian Processes for Bayesian Deconvolution and Source Separation

Lab Directed Research and Development Open House, March 2018 Reconstruction of Latent Signals from Mixed Measurements: Applications to Non-linear X-ray Spectroscopy

Gordon Research Conference (GRC) Metals in Biology, January 2017 High Throughput Transient X-ray Crystallography and Emission Spectroscopy on the Metalloenzymes at an X-ray Free Electron Laser

International Photosynthesis Congress, August 2016 Transient X-ray Crystallography and Emission Spectroscopy on the PSII OEC at an X-ray Free Electron Laser using a High Throughput Instrument.

Light Harvesting Satellite Meeting, August 2013 Energy Transfer and Coherent Dynamics Observed with Broadband 2D Electronic Spectroscopy of the Photosystem II Reaction Center.

Chemical and Biophysics Symposium, April 2012 Towards Broadband Two-Dimensional Electronic Spectroscopy of Photo-System II in Spinach.

2nd Annual External Workshop CSTEC, May 2011 Modeling Signatures of Vibronic Coupling in Two Dimensional Electronic Spectroscopy.

Midwest/Southeast Photosynthesis Meeting, November 2010 Decay Associated Analysis of Multidimensional Spectroscopy on Photosystem II Reaction Centers.

1st Annual External Workshop CSTEC, April 2010 Pulse Compression for Tunable Broadband and Continuum Ultrafast Pulses in the Visible and near-IR Regimes.

UROP Symposium at University of Minnesota, April 2008 Diffusion of DNA-binding Protein in a Solution of DNA.

Honors / Awards / Grants

Honor	Date
Panofsky Fellowship	November 2017 - Oct 2022
NIH Ruth Kirschstein (F32) Postdoctoral Fellowship	September 2015-2017
Rackham Travel Grant	August 2013.

Mentorship, Teaching, Service

Courses Taught:

Physics 1301W (University of Minnesota, 2007-2008): I taught a lab section of this course, graded tests, held office hours to answer student questions.

Undergraduate students that I have mentored:

Student	Date
Valentin Urena Baltazar, UC Santa Cruz Skill Taught: Raytracing, mathematica, and use of automatic differentiation for optimization problems.	Summer 2019
Samantha Tetef, University of Rochester Skills Taught: Tensor decomposition, neural network design for Cryo EM applications	Summer 2018
William Schultz, Stanford Skills Taught: EPICS control software development, data fitting in Python, motor control.	Spring 2015
Henry Wilson, University of Michigan Skills Taught: how to purify photosystem II reaction center, and helped him develop procedures for testing purity of functional photosystem II core complexes. Methods included denaturing protein gels, liquid chromatography, and 77K fluorescence.	2012-2013
Alex Parker, University of Michigan Skills Taught: how to purify BBY particles, and helped him develop procedures for purifying similar complexes from cyanobacterium (Acaryochloris Marina). Methods included centrifugation, liquid chromatography, and salt precipitation.	2011-2012

Postdoctoral Scholars Mentored

Scholar	Date
Chantal Mustoe, now at University of Strathclyde as a Crystallisation Fellow.	April 2020 - April 2021
Anton Loukianov, now at Unlearn AI (a start up company in the bay area)	December 2017 - Aug 2019

Proposal Review Commitees

Panel	Date
SLAC Lab Directed Research and Development Machine Learning Review Panel for FY21	May 2020
SLAC Lab Directed Research and Development Chemical Sciences Review Panel for FY20	May 2019
DOE Review of a continuation to DE-FOA-0002181	April 2020
NIH Review of X02 facility grant (pre-review)	October 2018

Franklin Fuller